SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Sarolaner is a member of the isoxazoline class of parasiticides and the chemical name is 1‑(5’‑((5S)‑5‑(3,5‑Dichloro‑4‑fluorophenyl)‑5‑(trifluoromethyl)‑4,5‑dihydroisoxazol‑ 3‑yl)‑3’‑H‑spiro(azetidine‑3,1’‑(2) benzofuran)‑1‑yl)‑2‑(methylsulfonyl)ethanone. SIMPARICA TRIO contains the S‑enantiomer of sarolaner. Moxidectin is a semi‑synthetic methoxime derivative of nemadectin which is a fermentation product of Streptomyces cyaneogriseus subspecies noncyanogenus. Moxidectin is a pentacyclic 16-membered lactone macrolide. The chemical name for moxidectin is (6R,23E,25S)-5-O-Demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1buten-1-yl]-6,28-epoxy-23-(methoxyimino)milbemycin B. Pyrantel belongs to a family classified chemically as tetrahydropyrimidines and the chemical name is (E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl) vinyl] pyrimidine 4,4’ methylenebis [3-hydroxy-2-naphthoate](1:1). It is a yellow, water-insoluble crystalline salt of the tetrahydropyrimidine base and pamoic acid containing 34.7% base activity. INDICATIONS SIMPARICA TRIO is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections.